Neurowell Clinical Research
Our PTSD Research
We're evaluating whether an investigational combination of two long-approved treatments can help restore healthy brain energy signaling in PTSD. This IRB oversight study provides active treatment, no placebo, clinical monitoring, and personalized dose optimization.
IRB Oversight
Institutional review board approved protocol
Active Treatment – No Placebo
Every participant receives active treatment
Specialist Care Team
Led by board-certified physicians
Targeting Brain Energy,Not Just Symptoms
Emerging research suggests PTSD involves disrupted astrocyte-neuron energy support and dysregulated cellular "energy switches." HB-01 is designed to address these pathways by combining two established medicines to support energy production and coordination. Use in PTSD is investigational and is being evaluated in this trial.
Energy support hypothesis
Improve mitochondrial output and fuel routing to key circuits.
Network coordination hypothesis
Normalize astrocyte signaling to reduce 'energy crisis' states.
Whole-person monitoring
Cognitive, functional, and safety assessments at each visit.
HB-01 (Two Components, Dual Target)
PPAR-γ Pathway Support
A long-approved treatment hypothesized to help shift astrocytes from "conserve" to "support" mode and bolster mitochondrial efficiency. Safety monitored throughout.
Calcium Signaling Balance
A well-established medicine hypothesized to stabilize astrocyte activity and reduce inefficient over-excitation in stress networks.
Rationale: Pairing production + distribution support may yield broader effects than either alone.
Eligibility Snapshot
Likely Candidates
Key Exclusions
Metabolic Mismatch
Under stress, astrocytes may prioritize conservation over support, reducing efficient fuel delivery to circuits that govern cognition and emotion.
Cellular "Switches"
Energy Sensing
AMPK/mTOR signaling helps cells balance survival vs. performance; dysregulation is an active research focus in stress-related disorders.
Network Effects
Calcium Coordination
Astrocyte calcium activity coordinates local networks; instability can impair synchrony and resilience under stress.
"It felt like someone turned the lights back on. I could think clearly and be present again."
, Study participant, Week 8 (individual experience; results vary)
Three Simple Steps
Screen
Confidential call to review history and eligibility.
Evaluate
Baseline visit, labs as indicated, and assessments.
Begin
Start HB-01 with regular check-ins and optimization.
Take the First Step
Our research team will answer questions and discuss eligibility.
Frequently Asked Questions
Important Information & Disclaimers: HB-01 combines two FDA-approved treatments for other conditions. Its safety and efficacy for PTSD are investigational and are being evaluated in this IRB oversight clinical study. The information above is not medical advice. You will receive and should review the informed consent documents before deciding whether to participate.