Link vs Proof

Other Alzheimer’s disease experts note that these studies are largely observational so they are proof only of an association between diet and cognition. “The only way to prove that a dietary intervention—or any intervention—is effective is through a randomized controlled trial,” says David S. Knopman, MD, FAAN, professor of neurology at the Mayo Clinic in Rochester, MN. “Observational studies are subject to a variety of biases, including the many related lifestyle choices that people may follow—avoidance of other foods, exercise, intellectual engagement, or other health-conscious habits. That makes it almost impossible to isolate a dietary pattern from all those other things.”

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